EXCITABILITY CONSTRAINTS ON VOLTAGE-GATED SODIUM CHANNELS.

Excitability constraints on voltage-gated sodium channels.

We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels.The primary function michael harris ii headband of sodium channels is to allow the propagation of action potentials.Since Hodgkin and Huxley, mathematical models have suggested that sodium channel properties need to be tightl

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Evidence summary of lifestyle interventions in adults with metabolic dysfunction-associated steatotic liver disease

ObjectiveIn this study, our objective was to provide practice recommendations by thoroughly examining lifestyle interventions for adults diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD).This was graco ascent achieved through a systematic review of the literature, specifically focusing on lifestyle modification interve

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Investigating crash-related injuries between animal-related and motor vehicle in Rural China: Bayesian random parameter probit model considering endogenous variables

AbstractThis study intended to investigate the injury severity of animal-vehicle crashes (AVCs) and identify the contributing factors from the perspective of animals.To achieve this objective, Bayesian random parameter probit regression model with endogenous variable was proposed with a case study application on two places in Inner Mongolia, China.

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Sediment as a constituent of Mediterranean benthic communities dominated by Caulerpa racemosa var. cylindracea

Mediterranean macroalgal assemblages in areas invaded and non-invaded by Caulerpa racemosa var.cylindracea were compared and trapped sediments were characterised.Results showed that assemblages invaded by C.racemosa var.cylindracea differed greatly from non-invaded ones: encrusting and erect algae, both articulated and foliose, decreased in invaded

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Anomaly detection using Deep Autoencoders for the assessment of the quality of the data acquired by the CMS experiment

The certification of the CMS experiment data as usable for physics analysis is a crucial task to ensure the quality of all physics results published by the collaboration.Currently, the certification conducted by human experts is labor intensive and based on the scrutiny of distributions integrated on several hours of data taking.This contribution f

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